
Overview
The ASUS PRIME X399-A is the prime choice for prosumers and content creators featuring 1-click overclocking with 5-Way Optimization, ASUS Pro Clock Technology, and multiple GPU support with SafeSlot protection. Dual M.2 and front-panel USB 3.1 deliver optimized data speeds, while AURA Sync lighting and 3D-printing mounts provide unlimited personalization.
At-a-Glance:
- Powered by AMD Ryzen Threadripper TR4 processors
- 5-Way Optimization featuring Auto-Tuning and FanXpert 4
- Patent-pending SafeSlot (3X)
- Unmatched Personalization
- 8-channel HD audio

One-click overclock and cooling, done
ASUS 5-Way Optimization dynamically optimizes essential aspects of the system, providing overclocking and cooling profiles that are tailored for your rig.
Ultra-Fast ConnectivitySpeed up with onboard dual M.2 up to 32Gbps and keep your SSD cooler with an ultra-efficient heatsink. Future-proof connectivity with the Prime X399-A’s front panel USB 3.1, ready for next-gen PC cases and devices. Lastly, with the U.2 connector, experience fast data-transfer speeds and free up a PCIe slot for another expansion card. | Protect your Graphics Card InvestmentSafeSlot is the PCIe slot reinvented by ASUS and engineered to provide superior retention and shearing resistance. Manufactured in a single step using a new insert-molding process, SafeSlot integrates the slot with fortifying metal for an inherently stronger slot, which is then firmly anchored to the PCB through additional solder points. | Make it your ownASUS Aura offers full RGB lighting control with a variety of functional presets for the built-in RGB LEDs as well as strips connected to the onboard RGB headers. And it can all be synced with an ever-growing portfolio of Aura-capable ASUS hardware. Prime X399-A also includes 2 onboard RGB headers ready to sync lighting effects with different Aura Sync compatible products. |
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